1. Any of the following have a direct or substantial financial interest in the proposal: the review body member or the member's spouse, brother, sister, child, parent, father-in-law, mother-in-law, any business in which the member is then serving or has served within the previous two years, or in which the member is negotiating for or has an arrangement or understanding concerning prospective partnership or employment or is otherwise in a position of conflict of interest as determined by state law.

2. The member has a direct private interest in the proposal.

3. Any other valid reason for which the member has determined that participation in the hearing and decision cannot be in an impartial manner.